منابع مشابه
Kinetochore-Microtubule Interactions
Kinetochores are the multiprotein macromolecular assemblies on chromatin that ensure the accurate and timely segregation of chromosomes at duringmitosis. To achieve this, kinetochores must interact with the microtubules of the spindle andmicrotubule-associated proteins. The nature of the kinetochore–microtubule interaction varies during the stages of the mitotic cycle, starting with initial cap...
متن کاملCLASP2 phosphorylation regulates kinetochore-microtubule interactions
Error-free chromosome segregation requires dynamic control of microtubule attachment to kinetochores, but how kinetochore-microtubule interactions are spatially and temporally controlled during mitosis remains incompletely understood. In addition to the NDC80 microtubule-binding complex, other proteins with demonstrated microtubule-binding activities localize to kinetochores. One such protein i...
متن کاملAccurate phosphoregulation of kinetochore–microtubule affinity requires unconstrained molecular interactions
Accurate chromosome segregation relies on dynamic interactions between microtubules (MTs) and the NDC80 complex, a major kinetochore MT-binding component. Phosphorylation at multiple residues of its Hec1 subunit may tune kinetochore-MT binding affinity for diverse mitotic functions, but molecular details of such phosphoregulation remain elusive. Using quantitative analyses of mitotic progressio...
متن کاملEMBO Member’s Review Kinetochore–microtubule interactions: steps towards bi-orientation
Eukaryotic cells segregate their chromosomes accurately to opposite poles during mitosis, which is necessary for maintenance of their genetic integrity. This process mainly relies on the forces generated by kinetochore–microtubule (KT–MT) attachment. During prometaphase, the KT initially interacts with a single MT extending from a spindle pole and then moves towards a spindle pole. Subsequently...
متن کاملKinetochore-microtubule interactions: the means to the end.
Kinetochores are proteinaceous complexes containing dozens of components; they are assembled at centromeric DNA regions and provide the major microtubule attachment site on chromosomes during cell division. Recent studies have defined the kinetochore components comprising the direct interface with spindle microtubules, primarily through structural and functional analysis of the Ndc80 and Dam1 c...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations of Crystallography
سال: 2011
ISSN: 0108-7673
DOI: 10.1107/s0108767311099879